Publications

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program – Geukens T, De Schepper M, Van Den Bogaert W, Van Baelen K, Maetens M, Pabba A, Mahdami A,  Leduc S, Isnaldi E, Nguyen H-L, Bachir I, Hajipirloo M, Zels G, Van Cauwenberge J, Borremans K, Vandecaveye V, Weynand B, Vermeulen P, Leucci E, Baietti MF, Sflomos G, Battista L, Brisken C, Derksen PWB, Koorman T, Visser D, Scheele CLGJ, Thommen DS, Hatse S; Fendt S-M, Vanderheyden E, Van Brussel T, Schepers R, Boeckx B, Lambrechts D, Marano G, Biganzoli E, Smeets A, Nevelsteen I, Punie K, Neven P, Wildiers H, Richard F, Floris G, Desmedt C – NPJ Breast Cancer – Nature.com

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation – Urratia AA, Mesa-Ciller C, Guajardo-Grence A, Alkan HF, Soro-Arnáiz I, Vandekeere A, Ferreira Campos AM, Igelmann S, Fernández-Arroyo L, Rinaldi G, Lorendeau D, De Bock K, Fendt S-M, Aragonés J – Cell Reports – Sciencedirect.com

Metabolic signaling in cancer metastasis – Krieg S, Fernandes SI, Kolliopoulos C, Liu M, Fendt S-M – Cancer Discovery – AACRjournals.com

Aging‑accumulated methylmalonic acid serum levels at breast cancer diagnosis are not associated with distant metastases – Wu Q, Hatse S, Kenis C, Férnandez-García J, Altea-Manzano P, Billen J, Planque M, Vandekeere A, Lambrechts Y, Richard F, Punie K, Neven P, Smeets A, Nevelsteen I, Floris G, Desmedt C, Gomes AP, Fendt S-M, Wildiers H – Breast Cancer Research and Treatment – Springer.com

Metabolic heterogeneity in cancer - Demicco M, Liu X-Z, Leithner K, Fendt S-M - Nature Metabolism - Nature.com

Challenges and opportunities in targeting metabolism - Birsov K, Chandel N S, Fendt S-M, Green D R, Li X, Muoio D M - Cell Chemical Biology - Pubmed

Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty - Wu Q, Hatse S, Kenis C, Fernández Garcia J, Altea-Manzano P, Billen J, Planque M, Vandekeere A, Lambrechts Y, Richard F, Punie K, Neven P, Smeets A, Nevelsteen I, Floris G, Desmedt C, Gomes A P, Fendt S-M, Wildiers H - GeroScience - Pubmed

Loss of attachment promotes proline accumulation and axcretion in cancer cells - Pilley S E, Hennequart M, Vandekeere A, Blagih J, Legrave N M, Fendt S-M, Vousden K H, Lebuschagne C F - Science Advances - Pubmed

Spatial metabolomics principles and application to cancer research - Planque M, Igelmann S, Ferreira Campos AM, Fendt S-M - Current Opinion in Chemical Biology - Pubmed

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo - Reyes-Castellanos G, Abdel Hadi N, Gallardo-Arriaga S, Masoud R, Garcia J, Lac S, El Kaoutari A, Gicquel T, Planque M, Fendt S-M, Linares L K, Gayet O, Guillaumond F, Dusetti N, Iovanna J, Carrier A - iScience - iScience

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy - Talebi A, de Laat V, Spotbeen X, Dehairs J, Rambow F, Rogiers A, Vanderhoydonc F, Rizotto L, Planque M, Doglioni G, Motamedi S, Nittner D, Roskams T, Agostinis P, Bechter O, Boecxstaens V, Garmyn M, O'Farrel M, Wagman A, Kemble G, Leucci E, Fendt S-M, Marine JC, Swinnen J V - Journal of Experimental & Clinical Cancer Research - Pubmed

Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia - Shimobayashi M, Thomas A, Shetty S, Frei I C, Wölnerhanssen B K, Weissenberger D, Vandekeere A, Planque M, Dietz N, Ritz D, Meyer-Gerspach A C, Maier T, Hay N, Peterli R, Fendt S-M, Rohner N, Hall M N - eLife - Pubmed

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling - Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu XZ, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine JC, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt S-M - Nature Cancer - Pubmed

CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions - Liu P-S, Chen Y-T, Li X, Hsueh P-C, Tzeng S-F, Chen H, Shi P-Z, Xie X, Parik S, Planque M, Fendt S-M, Ho P-C - Nature Immunology - Pubmed

Mitochondria metabolism sets the species-specific tempo of neuronal development - Iwata R, Casimir P, Erkol E, Boubakar L, Planque M, Gallego López IM, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquière B, Fendt S-M, Vanderhaeghen P - Science - Pubmed

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution - Fleischer JR, Schmitt AM, Haas G, Xu X, Zeisberg EM, Bohnenberger H, Küffer S, Teuwen LA, Karras PJ, Beißbarth T, Bleckmann A, Planque M, Fendt S-M, Vermeulen P, Ghadimi M, Kalucka J, De Oliveira T, Conradi LC - Molecular Cancer - Pubmed

CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation - Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt - 2022 - Cell Reports - Pubmed

Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox recue in respiration-deficient cells - Patricia Altea-Manzano, Anke Vandekeere, Joy Edwards-Hicks, Mar Roldan, Emily Abraham, Xhordi Lleshi, Ania Naila Guerrieri, Domenica Berardi, Jimi Wills, Jair Marques Junior, Asimina Pantazi, Juan Carlos Acosta, Rosario M. Sanchez-Martin, Sarah-Maria Fendt, Miguel Martin-Hernandez, Andrew J. Finch - 2022 - Molecular Cell - Pubmed

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide - Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt - 2022 - Frontiers in Oncology - Frontiers

Metabolite-derived protein modifications modulating oncogenic signaling - Liu Y, Vandekeere A, Xu M, Fendt SM, Altea-Manzano P - Frontiers in Oncologie - Pubmed

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma - Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Steefan Christen, Thomas Hielscher, Martina Schnölzet, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, andreas van Deimling, Sarah-Maria Fendt, Violaine Goidts - 2022 - Nature Oncogenesis - Pubmed

Metastasis - Lyden D, Ghajar CM, Correia AL, Aguirre-Ghiso JA, Cai S, Rescigno M, Zhang P, Hu G, Fendt SM, Boire A, Weichselbaum RR, Katipally RR - Cancer Cell - Pubmed

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers - Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A G Duarte, Esther A Zaal, Ali Talebi, Matteo rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E M Baiden-Amissah, Gabe S Sonke, Hugo M Horlings, Guy Eelen, Emanuele Berardi, Johannes V Swinnen, Celia R Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniele Annibali, Frédéric Amant - 2022 - Nature Communications - Pubmed

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle - Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet - 2022 - Cell Reports - Pubmed

Research is a progress - Fendt SM - Nature Cell Biology - Pubmed

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis - Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M Cuadros, Juan Fernández-Gacia, Carla Riera-Domino, Cristina Jauset, Mélanie Planque, Hamza Furkan Alkan, David Nitter, Dongmei Zuo, Lindsey A Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M L Knott, Martin F Orth, Sofie Demeyer, Guy Eelen, Lacey E Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Soltar, Michael T Lewis, Harald Bartsch, Menfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimilliano Mazzone, Gregory J Hannon, Sophia Y Lunt, Thomas GP Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt - 2022 - Nature - Pubmed

Altered propionate metabolism contributes to tumour progression and aggressiveness - Ana Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B Nunes, Bethany E Schaffer, Anders P Mutvei, John M Asara, Lewis C Cantley, Sarah-Maria Fendt, John Blenis - 2022 - Nature Metabolism - Pubmed

Palmitic acid: Enabling the tumor's nerves - Hamza Furkan Alkan, Patricia Alteo-Manzano, Sarah-Maria Fendt - 2022 - Cell Metabolism - PubMed

Macrophages are metabolically heterogeneous within the tumor microenvironment - Xenia Geeraerts, Juan Fernández-Garcia, Felix J Hartmann, Kyra E De Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Beoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksander Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C Bendall, Damya Laoui, Jan Van den Bossche, Sarah-Maria Fendt, Jo A Van Ginderachter - 2021 - Cell Reports - Pubmed

PCK opposes mitochondrial respiration and maintains the radox balance in starving lung cancer cells - Gabriele Bluemel, Mélanie Planque, Corina T Madreiter-Sokolowski, Theresa Haitzmann, Andelko Hrzenjak, Wolfgang F Graier, Sarah-Maria Fendt, Horst Olschewski, Katharina Leithner - 2021 - Free Radical Biology and Medicine - Pubmed

More Metabolism! - James A Olzmann, Sarah-Maria Fendt, Yatrik Shah, Karen Vousden, Navdeep Chandel, Tiffany Horng, Nika Danial, Benjamin Tu, Heather Christofk, Matthew G Vander Heiden, Kathryn Wellen - 2021 - Molecular Cell - Pubmed

Nuclear PHGDH projects cancer cells from nutrient stress - Daniela Annibali, Sarah-Maria Fendt - 2021 - Nature Metabolism - Pubmed

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis - Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T Siveke, Monte M Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M Grüner - 2021 - Cell Reports - Pubmed

Lipid metabolism in cancer: New perspectives and emerging mechanisms - Lindsay A Broadfield, Antonino Alejandro Pane, Ali Talebi, Johannes V Swinnen, Sarah-Maria Fendt - 2021 - Developmental Cell - Pubmed

BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis - Mónica Vara-Pérez, Matteo Rossi, Chris Van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D Garg, Corentin Schepkens, Francesca M Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes V Swinnen, Jean Marie Colet, Joost J van den Oord, Sarah-Maria Fendt, Massimiliano Mazzone, Patrizia Agostinis - 2021 - The EMBO Journal - Pubmed

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System - Katrien Neyrinck, Johanna Van Den Daele, Tim Vervliet, Jonathan De Smedt, Keimpe Wierda 5, Melissa Nijs, Tom Vanbokhoven, Astrid D'hondt, Mélanie Planque, Sarah-Maria Fendt, Pei-Yu Shih, Frederik Seibt, Juan Pita Almenar, Mohamed Kreir, Devesh Kumar, Vania Broccoli, Geert Bultynck, Andreas Ebneth, Alfredo Cabrera-Socorro, Catherine Verfaillie - 2021 - Stem Cell Reviews and Reports - Pubmed

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids - Erica Pranzini, Elisa Pardella, Paolo Paoli, Sarah-Maria Fendt, Maria Letizia Taddei - 2021 - Trends in Cancer - Pubmed

Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis - L A Broadfield, J A Gonçalves Duarte, R Schmieder, D Broekaert, K Veys, M Planque, K Vriens, Y Karasawa, F Napolitano, S Fujita, M Fujii, M Eto, B Holvoet, R Vangoitsenhoven, J Fernandez-Garcia, J Van Elsen, J Dehairs, J Zeng, J Dooley, R Alba Rubio, J van Pelt, T G P Grünewald, A Liston, C Mathieu, C M Deroose, J V Swinnen, D Lambrechts, D di Bernardo, S Kuroda, K De Bock, S-M Fendt - 2021 - Cancer Research - Pubmed

Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo - Tiago De Oliveira, Tina Goldhardt, Marcus Edelmann, Torben Rogge, Karsten Rauch, Nikola Dobrinov Kyuchukov, Kerstin Menck, Annalen Bleckman, Joanna Kalucka, Shawez Khan, Jochen Gaedcke, Martin Haubrock, Tim Beissbarth, Hanibal Bohnenberger, Mélanie Planque, Sarah-Maria Fendt, Lutz Ackermann, Michael Ghadimi, Lena-Christin Conradi - 2021 - Cancers - Pubmed

The metabolism of cancer cells during metastasis - Gabriele Bergers and Sarah-Maria Fendt - 2021 - Nature Reviews Cancer - PubMed

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth - Shauni Lien Geeraerts, Kim Rosalie Kampen, Gianmarco Rinaldi, Purvi Gupta, Mélanie Planque, Nikolaos Louros, Elien Heylen, Kaat De Cremer, Katrijn De Brucker, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, Frederic Rousseau, David Cassiman, Sarah-Maria Fendt, Arnout Voet, Bruno P A Cammue, Karin Thevissen, Kim De Keersmaecker - 2021 - Molecular Cancer Therapeutics - Pubmed

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition - Gianmarco Rinaldi , Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W Hunter, Sophia Y Lunt, Thomas G P Grünewald, Sarah-Maria Fendt - 2021 - Molecular Cell - Pubmed

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy - Sarah-Maria Fendt, Christian Frezza and Ayelet Erez - 2020 - CANCER DISCOVERY - Pubmed

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1 - Christensen, Emily M.; Bogner, Alexandra N.; Vandekeere, Anke; Tam, Gabriela S.; Patel, Sagar M.; Becker, Donald F.; Fendt, Sarah-Maria; Tanner, John J. - 2020 - Journal of Biological Chemistry - Pubmed

Nutrient metabolism and cancer in the in vivo context: A metabolic game of give and take - Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt - 2020 - EMBO reports - Pubmed

Cancer cells stock up in lymph vessels to survive - Barbara M Grüner, Sarah-Maria Fendt - 2020 - NATURE - Pubmed

Age-induced accumulation of methylmalonic acid promotes tumour progression - Gomes, Ana P.; Ilter, Didem; Low, Vivien; Endress, Jennifer E.; Fernandez-Garcia, Juan; Rosenzweig, Adam; Schild, Tanya; Broekaert, Dorien; Ahmed, Adnan; Planque, Melanie; Elia, Ilaria; Han, Julie; Kinzig, Charles; Mullarky, Edouard; Mutvei, Anders P.; Asara, John; de Cabo, Rafael; Cantley, Lewis C.; Dephoure, Noah; Fendt, Sarah-Maria; Blenis, John - 2020 - NATURE - Pubmed

Pyrvinium pamoate induces death of triple-negative breast cancer stem-like cells and reduces metastases through effects on lipid anabolism. - Dattilo, Rosanna; Mottini, Carla; Camera, Emanuela; Lamolinara, Alessia; Auslander, Noam; Doglioni, Ginevra; Muscolini, Michela; Tang, Wei; Planque, Melanie; Ercolani, Cristiana; Buglioni, Simonetta; Manni, Isabella; Trisciuoglio, Daniela; Boe, Alessandra; Grande, Sveva; Luciani, Anna Maria; Iezzi, Manuela; Ciliberto, Gennaro; Ambs, Stefan; De Maria, Ruggero; Fendt, Sarah-Maria; Ruppin, Eytan; Cardone, Luca - 2020 - Cancer research - Pubmed

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis - Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M Winkelkotte, Carina R Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F Orth, Thomas G P Grünewald, Almut Schulze, Sarah-Maria Fendt - 2020 - Cell Rep - Pubmed

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization - Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, Tong Tong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock - 2020 - Cell Metabolism - Pubmed

Glutamine Metabolism Controls Chondrocyte Identity and Function - Steve Stegen, Gianmarco Rinaldi, Shauni Loopmans, Ingrid Stockmans, Karen Moermans, Bernard Thienpont, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet - 2020 - Developmental Cell - Pubmed

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. - Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt S-M, Zanivan S, Leung HY - 2020 - Nat Commun - Pubmed

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity. - Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt S-M, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K - 2020 - Circ Res - Pubmed

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines. - Boon R, Kumar M, Tricot T, Elia I, Ordovas L, Jacobs F, One J, De Smedt J, Eelen G, Bird M, Roelandt P, Doglioni G, Vriens K, Rossi M, Vazquez MA, Vanwelden T, Chesnais F, El Taghdouini A, Najimi M, Sokal E, Cassiman D, Snoeys J, Monshouwer M, Hu WS, Lange C, Carmeliet P, Fendt SM, Verfaillie CM. - 2020 - Nat Commun. - Pubmed

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo. - Fernández-García J, Altea-Manzano P, Pranzini E, Fendt SM. - 2020 - Trends Biochem Sci. - Pubmed

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism. - Santoro V, Kovalenko I, Vriens K, Christen S, Bernthaler A, Haegebarth A, Fendt SM, Christian S. - 2020 - Oncotarget - Pubmed

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. - Wang H, Franco F, Tsui YC, Xie X, Trefny MP, Zappasodi R, Mohmood SR, Fernández-García J, Tsai CH, Schulze I, Picard F, Meylan E, Silverstein R, Goldberg I, Fendt SM, Wolchok JD, Merghoub T, Jandus C, Zippelius A, Ho PC. - 2020 - Nat Immunol. - Pubmed

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects. - Fendt SM, Lunt SY. - 2020 - Cancer Cell - Pubmed

Analyzing the Metabolism of Metastases in Mice. - Altea-Manzano P, Broekaert D, Duarte JAG, Fernández-García J, Planque M, Fendt SM. - 2020 - Methods Mol Biol. - Pubmed

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism. - Vandoorne T, Veys K, Guo W, Sicart A, Vints K, Swijsen A, Moisse M, Eelen G, Gounko NV, Fumagalli L, Fazal R, Germeys C, Quaegebeur A, Fendt S-M, Carmeliet P, Verfaillie C, Van Damme P, Ghesquière B, De Bock K, Van Den Bosch L. - 2019 - Nat Commun. - PubMed

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells. - Kampen KR, Fancello L, Girardi T, Rinaldi G, Planque M, Sulima SO1, Loayza-Puch F, Verbelen B, Vereecke S, Verbeeck J, Op de Beeck J, Royaert J, Vermeersch P, Cassiman D, Cools J, Agami R, Fiers M, Fendt S-M, De Keersmaecker K. - 2019 - Nat Commun. - PubMed

Interactions in the (Pre)metastatic Niche Support Metastasis Formation. - Doglioni G, Parik S, Fendt S-M. - 2019 - Front Oncol. - PubMed

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. - Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, van Gorsel M, Boon R, Escalona-Noguero C, Torrekens S, Verfaillie C, Verbeken E, Carmeliet G, Fendt S-M. - 2019 - Nature - PubMed

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. - Li X, Wenes M, Romero P, Huang SChing-Chen, Fendt S-M, Ho P-C. - 2019 - Nat Rev Clin Oncol - PubMed

HIF1alpha Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis. - Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Muelas MOrtega, Mesa-Ciller C, Turiel G, Bouthelier A et al. - 2019 - Cell Rep. - PubMed

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. - Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SYing, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernández-García J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong K-K, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, Deberardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, et all. - 2019 - Nature - PubMed

Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity. - Korf H, Plessis Jdu, van Pelt J, De Groote S, Cassiman D, Verbeke L, Ghesquière B, Fendt S-M, Bird MJ, Talebi A, Van Haele M, Feio-Azevedo R, Meelberghs L, Roskams T, Mookerjee RP, Mehta G, Jalan, iv R, Gustot T, Laleman W, Nevens F, van der Merwe SWillem. - 2019 - Gut. - PubMed

13C Tracer Analysis and Metabolomics in 3D Cultured Cancer Cells. - van Gorsel M, Elia I, Fendt S-M. - 2019 - Methods Mol Biol. - PubMed

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics. - Kalucka J, Ghesquière B, Fendt S-M, Carmeliet P. - 2019 - Methods Mol Biol. - PubMed

HIF-1alpha metabolically controls collagen synthesis and modification in chondrocytes. - Steve Stegen, Kjell Laperre, Guy Eelen, Gianmarco Rinaldi, Peter Fraisl, Sophie Torrekens, Riet Van Looveren, Shauni Loopmans, Geert Bultynck, Stefan Vinckier, Filip Meersman, Patrick H Maxwell, Jyoti Rai, MaryAnn Weis, David R Eyre, Bart Ghesquière, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet - 2019 - Nature - Pubmed

Metabolic vulnerabilities of metastasizing cancer cells. - Fendt S-M. - 2019 - BMC Biol. - PubMed

Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8 T Cells. - Fernández-García J, Fendt S-M. - 2019 - Methods Mol Biol. - PubMed

Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice. - Broekaert D, Fendt S-M. - 2019 - Methods Mol Biol. - PubMed

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL. - Kampen KR, Sulima SO, Verbelen B, Girardi T, Vereecke S, Rinaldi G, Verbeeck J, de Beeck JOp, Uyttebroeck A, Meijerink JPP, Moorman AV, Harrison CJ, Spincemaille P, Cools J, Cassiman D, Fendt S-M, Vermeersch P, De Keersmaecker K. - 2019 - Leukemia - PubMed